LB995 Salicylic acid attenuates UVA-induced photoaging by inhibiting extracellular matrix degradation

Ultraviolet A (UVA) radiation is one of the main causes skin photoaging. UVA principal component solar UV and penetrates deeper into than UVB UVC. Salicylic acid (SA) widely used in rejuvenation as a superficial chemical exfoliator has shown potential anti-photoaging property. However, role mechanism SA UVA-induced photoaging have not been fully addressed. In present study, we established mouse model by 10J/cm2/day exposure for 10 days, was applied 30 min before radiation. Topical pretreatment ameliorated coarseness induced photoaged model. Hematoxylin eosin (HE) Masson’s Trichrome staining were performed histopathological evaluation showed that remarkably inhibited extracellular matrix degradation UVA. Human fibroblasts isolated exposed to (8J/cm2) with pre-incubation investigation cellular events. Reactive oxygen species (ROS) expression evaluated flow cytometry indicated prevented ROS production NF-κB mRNA suppressed pretreatment, TNF-α, IL-6, MMP-1 well downregulated. Moreover, resulted higher cell number treated group prohibiting apoptosis Our finding prevents inhibiting human fibroblast.